There will always be differences between environments: development mode/Local, production mode/Render, etc. These differences need to be considered and configured as required for your own app in each environment.
Maybe start by following our React app guide: https://docs.render.com/deploy-create-react-app
If you’re still having issue after following the guide, please elaborate on your issue in as much detail as possible, e.g. URLs, any logs/error messages, reproduction steps, screenshots, etc. to show the problem you’re experiencing.
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